263 REGULATION OF MICROSOMAL PROSTAGLANDIN E2 SYNTHASE-1 AND 5-LIPOXYGENASE-ACTIVATING PROTEIN/5-LIPOXYGENASE BY 4-HYDROXYNONENAL IN OSTEOARTHRITIC CHONDROCYTES
نویسندگان
چکیده
منابع مشابه
Regulation of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase-activating protein/5-lipoxygenase by 4-hydroxynonenal in human osteoarthritic chondrocytes
INTRODUCTION This study aimed to investigate whether hydroxynonenal (HNE) depletion is responsible for the switch from cyclooxygenase-2 (COX-2) and microsomal prostaglandin E2 synthase-1 (mPGES-1) to 5-lipoxygenase-activating protein (FLAP) and 5-lipoxygenase (5-LOX). METHODS For COX-2 and mPGES-1 studies, human osteoarthritic chondrocytes were stimulated at different incubation times (up to ...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2009
ISSN: 1063-4584
DOI: 10.1016/s1063-4584(09)60285-5